Preheat your oven to 375°F. Line a baking sheet with parchment paper.
In a large mixing bowl, combine the ground sausage and softened cream cheese. Mix until well blended.
Add the drained Rotel, shredded cheddar cheese, flour, garlic powder, onion powder, black pepper, salt, and baking powder to the bowl. Mix until all ingredients are thoroughly combined.
Using your hands, form the mixture into 1-inch balls and place them on the prepared baking sheet, spacing them about 1 inch apart.
Bake in the preheated oven for 20-25 minutes or until the sausage balls are golden brown and cooked through.
Remove from the oven and let cool for a few minutes before serving.