Preheat your oven to 400°F. Line a baking sheet with parchment paper or lightly grease it.
In a bowl, combine panko breadcrumbs, olive oil, garlic powder, onion powder, dried parsley, salt, black pepper, and Parmesan cheese. Mix until the breadcrumbs are evenly coated with oil and spices.
Pat the salmon fillets dry with paper towels. Place them skin-side down on the prepared baking sheet.
Brush the top of each fillet with Dijon mustard and drizzle with lemon juice.
Evenly distribute the panko mixture over the top of each salmon fillet, pressing gently to adhere the crumbs.
Bake in the preheated oven for 12-15 minutes, or until the salmon is cooked through and the panko crust is golden brown.
For extra crispiness, you can broil the salmon for an additional 1-2 minutes at the end of cooking.
Let the salmon rest for a few minutes before serving.