Preheat your oven to 350°F (175°C).
In a large mixing bowl, combine the shredded chicken, cream cheese, Greek yogurt, 1/2 cup of the shredded cheddar cheese, salsa, garlic powder, onion powder, cumin, chili powder, salt, and pepper. Mix until well combined.
Lay out the tortillas on a clean surface. Spoon about 1/4 cup of the chicken mixture onto each tortilla, then roll them up tightly and place them seam-side down in a greased 9x13 inch baking dish.
Once all tortillas are filled and placed in the dish, pour any remaining salsa over the top and sprinkle with the remaining 1/2 cup of shredded cheddar cheese.
Cover the dish with aluminum foil and bake in the preheated oven for 20 minutes.
Remove the foil and bake for an additional 10 minutes, or until the cheese is bubbly and slightly golden.
Remove from the oven and let cool for a few minutes. Garnish with chopped cilantro if desired before serving.