As I pulled the bubbling casserole from the oven, the aroma of savory ground beef and melted cheese wafted through my kitchen, wrapping me in a warm embrace of comfort. This Easy Homemade Ground Beef Casserole with Cheesy Penne has become a cherished go-to for my family, especially on those hectic weeknights when time slips away. With just a handful of familiar ingredients, I can whip up a satisfying, one-pan meal that pleases even the pickiest eaters. Not only is this dish a crowd-pleaser, but it also makes prepping dinner feel effortless. Plus, the leftovers? Perfect for lunch the next day! Curious about how this simple yet delightful recipe comes together? Let’s dive in!

Why Will You Love This Casserole?

Easy Prep: This Homemade Ground Beef Casserole is designed for busy lives, requiring minimal effort with just one pan.

Family Favorite: Packed with flavors that appeal to all ages, it’s the perfect dish for family dinners or casual gatherings.

Gooey Goodness: The melted cheddar cheese creates a delightful topping that elevates every bite, adding richness.

Nutritional Boost: Feel free to toss in vegetables like spinach or bell peppers for a wholesome twist, keeping dinner fun and nutritious.

Delicious Leftovers: This casserole heats up beautifully, making it a go-to for quick lunches or easy weeknight meals. So whether you serve it alongside a fresh Caesar salad or enjoy it solo, you’ll find comfort in every serving. For more easy and hearty recipes, check out this Beef Garlic Butter or Mongolian Ground Beef.

Homemade Ground Beef Casserole Ingredients

For the Casserole

Penne Pasta – Base of the casserole; be sure to cook it al dente for the best texture.
Ground Beef – Provides protein and flavor; using 85/15 fat content balances richness without being greasy.
Olive Oil – Used for sautéing; it boosts flavor, but you can substitute with vegetable oil if preferred.
Onion – Adds aromatic sweetness; feel free to use shallots for a more subtle taste.
Garlic – Enhances flavor with its fragrant kick; fresh minced garlic is always best.
Marinara Sauce – Moistens the dish and adds flavor; Rao’s Homemade is a favorite, but any quality brand works.
Salt and Black Pepper – Essential for seasoning; freshly cracked black pepper really elevates the taste.

For the Topping

Cheddar Cheese – Adds creaminess and depth; use shredded for the best melting result and feel free to swap for another melting cheese if desired.

Step‑by‑Step Instructions for Homemade Ground Beef Casserole

Step 1: Preheat and Prepare
Begin by preheating your oven to 400°F (200°C). While the oven warms up, grab a 9×13 inch baking dish and generously grease it with non-stick spray or a bit of olive oil. In this preparation phase, dice your onion and mince the garlic, ensuring that each component is ready to create a delightful flavor base for your Homemade Ground Beef Casserole.

Step 2: Cook the Penne Pasta
Next, fill a large pot with salted water and bring it to a rolling boil. Add the penne pasta and allow it to cook for about 7-8 minutes, or until it’s slightly under al dente. This will help maintain the perfect texture once combined in the casserole. When done, drain the pasta and set it aside while you move on to the beef.

Step 3: Brown the Ground Beef
In a skillet over medium-high heat, pour in a tablespoon of olive oil and let it heat up. Add the diced onion. Sauté the onion for about 2 minutes until it starts to soften, then introduce the ground beef. Cook for 8-10 minutes, breaking it apart as it cooks, until the beef is well browned and the onions are tender and translucent. Drain any excess fat to ensure your casserole isn’t greasy.

Step 4: Add the Garlic
After the beef is browned, it’s time to enhance the flavors. Stir in the minced garlic to the skillet, and cook for an additional 30 seconds. You’ll know it’s ready when the garlic becomes fragrant and golden, adding a beautiful depth to your Homemade Ground Beef Casserole’s flavor profile.

Step 5: Combine Marinara Sauce
Pour your chosen marinara sauce into the skillet with the beef and onions. Stir well to combine everything, then season generously with salt and freshly cracked black pepper. Let this mixture simmer for about 1-2 minutes, allowing the flavors to meld together beautifully and create a rich sauce.

Step 6: Assemble the Casserole
Take the drained penne pasta and add it to the baking dish. Pour the flavorful beef and marinara mixture on top, and then gently mix everything together using a spatula until thoroughly combined. This ensures that every bite of your Homemade Ground Beef Casserole is infused with the delectable flavors you’ve created.

Step 7: Add the Cheddar Cheese
Now it’s time to elevate your casserole! Sprinkle a generous layer of shredded cheddar cheese evenly over the top of the pasta and beef mixture. This layer of cheese will melt into a gooey, delicious topping that everyone will enjoy, making it truly irresistible.

Step 8: Bake to Perfection
Place the assembled casserole in your preheated oven and bake for about 10 minutes. Keep a close eye on it, and look for the cheese to be melted and beautifully golden. This step adds a deliciously bubbly texture to the top layer, perfectly complementing the savory flavors underneath.

Step 9: Cool Slightly and Serve
Once baked, remove the casserole from the oven and let it sit for 2-3 minutes. This allows the cheese to set, making it easier to serve. Dish up generous portions of your Homemade Ground Beef Casserole, and relish in the aroma and comfort this dish brings to your table.

Homemade Ground Beef Casserole Variations

Feel free to add your own personal touch to this comforting casserole and make it your family’s favorite!

Pasta Substitute: Try swapping penne for fusilli or whole wheat pasta for a different texture and flavor.
Vegetable Boost: Add diced carrots, mushrooms, or peas for extra nutrition and flavor. They’ll blend in perfectly with the beef.
Spicy Kick: Mix in some red pepper flakes to the beef mixture for a delightful heat that family members can adjust to their preference.
Herb Infusion: Sprinkle dried Italian herbs or fresh parsley into the meat sauce for an aromatic twist that enhances the comfort of the dish.
Different Cheese: Swap cheddar for Monterey Jack or a zesty pepper jack for an extra layer of flavor and heat.
Creamy Addition: Stir in a dollop of sour cream or cream cheese before baking for a richer, creamier casserole.
Taco Twist: Use taco seasoning instead of salt and pepper to create a flavorful twist, offering a festive flair to the casserole.
Zucchini Noodles: For a low-carb version, substitute traditional pasta with spiralized zucchini, making this dish lighter and more nutritious.

Enjoy these variations for some exciting new takes on your beloved ground beef casserole! For more inspiration, don’t hesitate to explore my recipe for Black Pepper Beef or try my perfectly balanced Healthier Garlic Beef.

What to Serve with Easy Homemade Ground Beef Casserole?

As you gather around the table, complement the hearty flavors of your casserole with delightful side dishes that elevate your meal’s experience.

Garlic Bread: The warm, buttery crunch of garlic bread enhances the comforting feel of the casserole, perfect for sopping up marinara sauce.
Caesar Salad: Crisp romaine, tangy dressing, and crunchy croutons provide a refreshing contrast to the rich, cheesy casserole, creating a delightful balance. It pairs effortlessly for a complete meal that feels like a treat.
Roasted Vegetables: Seasonal roasted veggies, like carrots or Brussels sprouts, add a colorful and nutritious touch, while their caramelized sweetness contrasts beautifully with savory notes.
Steamed Broccoli: Fresh, bright green broccoli spears offer a tender and nutritious side, helping to cut through the casserole’s richness and adding vibrant color to your plate.
Coleslaw: This crunchy cabbage salad offers a tangy, creamy contrast that complements the casserole and brings an exciting crunch to every bite.
Red Wine: A glass of bold red wine, such as Merlot, pairs beautifully with the savory flavors, enhancing the overall dining experience and bringing warmth to your meal.
Chocolate Chip Cookies: End your comforting dinner on a sweet note with freshly baked chocolate chip cookies. Their gooey chocolate complements the hearty casserole, creating a cozy finish to your meal.

How to Store and Freeze Homemade Ground Beef Casserole

Fridge: Store in an airtight container for up to 4 days. Allow the casserole to cool completely before covering to prevent condensation build-up.

Freezer: Freeze in a tightly sealed container for up to 3 months. For best results, let it cool fully before freezing to maintain texture and flavor.

Reheating: When ready to enjoy, thaw overnight in the fridge. Reheat in a preheated oven at 350°F for about 20 minutes, or microwave individual portions until heated through.

Leftovers: Remember, leftover Homemade Ground Beef Casserole makes a wonderful lunch option, easy to pack and reheat for busy days!

Make Ahead Options

These Easy Homemade Ground Beef Casseroles are perfect for meal prep! You can cook the penne pasta and brown the ground beef up to 24 hours in advance. Simply sauté the onions and garlic with the beef, then allow the mixture to cool before storing it in an airtight container in the fridge. You can also mix together the marinara sauce and seasoning beforehand to deepen the flavors. When you’re ready to bake, combine the pasta, beef mixture, and cheese in the baking dish, then bake at 400°F (200°C) for about 10 minutes until the cheese is melted. By preparing in advance, you’ll save precious time on busy weeknights while enjoying a delicious, home-cooked meal!

Expert Tips for Homemade Ground Beef Casserole

Perfect Pasta: Cook penne just until slightly under al dente to prevent mushiness. Aiming for 7-8 minutes ensures the ideal texture post-bake.
Grease-Free Beef: Drain excess fat thoroughly after browning the ground beef. This prevents a greasy texture, letting the casserole shine in flavor.
Watch the Cheese: Monitor the cheese during the last few minutes of baking; if it browns too quickly, cover it lightly with foil to keep it creamy.
Sauce Sufficiency: If your mixture looks dry before baking, add an extra ¼ cup of marinara sauce. This keeps the Homemade Ground Beef Casserole moist and flavorful.

Homemade Ground Beef Casserole Recipe FAQs

What type of penne pasta should I use for the casserole?
I recommend using regular penne pasta for the best texture, but you can also opt for whole wheat penne if you prefer a healthier option. Just be sure to cook it al dente, as it will continue to cook while baking!

How should I store the leftovers?
Store any leftover Homemade Ground Beef Casserole in an airtight container in the fridge for up to 4 days. Allow it to cool completely before sealing to avoid condensation, which can make it soggy.

Can I freeze this casserole for later?
Absolutely! To freeze, let the Homemade Ground Beef Casserole cool fully, then transfer it to a tightly sealed container or freezer bag. It can be frozen for up to 3 months. When you’re ready to enjoy it, thaw it overnight in the refrigerator before reheating.

Why is my casserole too greasy?
To avoid a greasy texture, ensure you drain the excess fat from the ground beef after browning it. Also, be mindful of using a leaner meat; 85/15 fat content is great for flavor without adding unnecessary grease.

Can I add vegetables to the casserole?
Very! You can absolutely add diced vegetables like bell peppers, spinach, or zucchini for extra nutrition and flavor. Just subtly sauté them with the onions before adding the ground beef to ensure they cook through nicely.

What if my casserole looks dry before baking?
If you notice that the mixture appears too dry, you can mix in an extra ¼ cup of marinara sauce before baking. This will help keep your Homemade Ground Beef Casserole moist and delicious as it bakes.